Antiretroviral therapy (ART) and condom use have been proven to reduce the risk of sexual transmission of human immunodeficiency virus (HIV) among HIV sero-different couples, but its full implementation remains a challenge.This study aims to assess life extension blueberry extract HIV seroconversion rate of HIV-negative spouse and its associated risk factors among HIV sero-different couples in rural China.An open cohort of HIV sero-different couples enrolled in 30 counties in China between October 1, 2010, and September 30, 2012, and followed-up to December 31, 2012, was constructed retrospectively.A nested case-control study of risk factors of HIV seroconversion among sero-different couples was conducted in April and May of 2013, based on the open cohort.
Sero-different couples with the HIV-negative spouse seroconverting at least 3 months after the previous negative diagnosis during cohort observation period were labeled as "case couples".The "control couples" were selected randomly from the same cohort that did not have the HIV-negative spouse seroconversion during the same period.The "case couples" and "control couples" were matched on gender, age, and region of residence.Sexual behaviors among HIV sero-different couples before and after the index spouses notifying their HIV infection status to their HIV-negative spouses were collected via face-to-face interview.
Univariate and multivariate logistic regression models were used to assess factors associated with HIV seroconversion among HIV sero-different couples.Of 4481 HIV sero-different couples, a total of 53 seroconversions were observed within 5218 person-years of follow-up.The incidence rate was 1.02 (95%CI: 0.
76-1.33) per 100 person-years.Forty "case couples" confirmed HIV-negative spouse seroconversions infected via marital sexual transmission, were matched to 80 "control couples".Of the 120 couples, 81(67.
5%) were receiving ART, and 70 (58.3%) reported consistently used condoms during intercourse after the index spouse was diagnosed HIV infection.Multivariate conditional logistic regression analysis showed that the desire to conceive a child (OR = 5.18, 95% CI: 1.
19-22.58) hogwarts legacy grab significantly increased the odds of HIV seroconversion.Protective factors of spousal HIV seroconversion were currently receiving ART (OR = 0.09, 95% CI: 0.
01-0.67) and consistent condom use (OR = 0.05, 95% CI: 0.01-0.
28).Intention to conceive a child is the most important risk factor for HIV seroconversion among sero-different couples.Specific efforts on scientific use of ART to assist sero-different couples to achieve their wish to conceive a healthy child are needed to minimize the risk of HIV transmission.